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Understanding the Differences Between Motegrity vs Linzess: A Comprehensive Comparison

digestive health

Digestive health is vital to our well-being, often dictating how throughout the day. When it’s compromised, we turn to medication for relief.

Two prescribed drugs for digestive health are Motegrity and Linzess. Both are used to treat similar conditions. But there are subtle differences between them.

Read below to learn the differences and similarities between Motegrity vs Linzess.


Doctors prescribe both Motegrity and Linzess to treat chronic idiopathic constipation (CIC). Difficult or infrequent bowel movements characterize this condition.

But Linzess is also used to treat irritable bowel syndrome with constipation (IBS-C). Linzess can treat constipation. It results in bowel function improvement in patients.

Additionally, the recommended dosage differs between the two drugs. Motegrity is taken once a day, while Linzess is taken twice a day.

It’s important to follow your doctor’s dosage instructions. Never exceed the prescribed amount.


Motegrity vs Linzess are used for similar conditions. But, they work in the body. Motegrity increases fluid secretion in the intestines. This helps move stool through the digestive system. It can help with gastrointestinal disorders such as irritable bowel syndrome.

Linzess, is also known as Linaclotide. It works by activating specific receptors in the gut. This leads to increased fluid secretion and movement in the intestines. This helps to relieve constipation and abdominal discomfort associated with IBS-C.

Side Effects

As with any medication, there can be potential side effects of Motegrity vs Linzess. Some possible side effects of Motegrity include headache, nausea, and abdominal pain. Linzess also has similar side effects but may also cause diarrhea and bloating.

It’s important to discuss any potential side effects with a professional doctor. Report any changes or concerns while taking these medications. Your doctor may recommend starting with a lower dosage and increasing it to cut side effects.

Cost and Accessibility

Another difference between Motegrity and Linzess is their cost and accessibility. The price of prescription drugs can vary based on insurance plans and location.

Linzess does not have a generic alternative. It could be more expensive than Motegrity. This might be a consideration for long-term treatment plans.

Furthermore, insurance coverage for these drugs can differ depending on the provider. Some patients may have easier access to one medication over the other due to their insurance formulary.

It’s essential to check with your insurance provider. Consider these factors when choosing the most suitable and affordable option for your treatment.


Despite their differences, Motegrity and Linzess are effective for treating chronic constipation. They have also been approved by the Food and Drug Administration (FDA). It’s important to note that while these medications can provide relief, they do not cure the underlying causes of CIC or IBS-C.

Motegrity and Linzess should be used as directed and with a healthy diet and lifestyle to promote overall digestive health. It’s also important to note that these medications may take time to show results, so patience is vital when starting a new treatment plan.

Differentiating Motegrity vs Linzess

Motegrity vs Linzess are both drugs that are used for similar conditions. They have subtle differences in their usage, effects, and accessibility. It’s crucial to consult with your doctor to determine which option is best for you based on your specific needs and medical history.

Always follow your doctor’s instructions and report any concerns or side effects while taking these medications.

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Written by Mia

Hey Everyone! This is Mia Shannon from Taxes. I'm 28 years old a professional blogger and writer. I've been blogging and writing for 10 years. Here I talk about various topics such as Fashion, Beauty, Health & Fitness, Lifestyle, and Home Hacks, etc. Read my latest stories.

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